Dysregulation of endocannabinoid concentrations in human subcutaneous adipose tissue in obesity and modulation by omega-3 polyunsaturated fatty acids

Abstract Obesity is believed to be associated with a dysregulated endocannabinoid system which may reflect enhanced inflammation. However, reports of this in human white adipose tissue (WAT) are limited and inconclusive. Marine long-chain omega-3 polyunsaturated fatty acids (LC n-3 PUFAs) have anti-inflammatory actions therefore improve obesity-associated Therefore, acid (FA) concentrations, gene expression were assessed subcutaneous WAT (scWAT) biopsies from healthy normal weight individuals (BMI 18.5–25 kg/m2) living metabolically obesity 30–40 prior following 12-week intervention 3 g fish oil/day (1.1 eicosapentaenoic (EPA) + 0.8 DHA) or corn (placebo). had higher n-6 PUFAs EPA, concentrations two endocannabinoids (anandamide (AEA) eicosapentaenoyl ethanolamide (EPEA)), phospholipase A2 Group IID (PLA2G2D) IVA (PLA2G4A), lower CNR1. In response oil intervention, EPA increased similar extent both BMI groups, DHA by greater individuals. EPEA docosahexaenoyl (DHEA) only 2-arachidonyl glycerol (2-AG) decreased only. Altered acid, endocannabinoid, profiles at baseline linked. incorporates when their intake affects the system; however, effects appear than those obesity.